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Index > Protein center > SELL(Gene name) > Human
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  • SELL (Gene name),
  • L-selectin (Protein name ),  LYAM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SELL(LNHR;LYAM1);
    Protein name:
    L-selectin;
    Alternative:
    Leukocyte adhesion molecule 1(LAM-1);CD62 antigen-like family member L;Leukocyte-endothelial cell adhesion molecule 1(LECAM1);Leukocyte surface antigen Leu-8;TQ1;Lymph node homing receptor;gp90-MEL;
    CD:
    CD62L;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding.
    Function:
    Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    372
    Sequence:
    50:
    MIFPWKCQST | QRDLWNIFKL | WGWTMLCCDF | LAHHGTDCWT | YHYSEKPMNW | 
    100:
    QRARRFCRDN | YTDLVAIQNK | AEIEYLEKTL | PFSRSYYWIG | IRKIGGIWTW | 
    150:
    VGTNKSLTEE | AENWGDGEPN | NKKNKEDCVE | IYIKRNKDAG | KWNDDACHKL | 
    200:
    KAALCYTASC | QPWSCSGHGE | CVEIINNYTC | NCDVGYYGPQ | CQFVIQCEPL | 
    250:
    EAPELGTMDC | THPLGNFSFS | SQCAFSCSEG | TNLTGIEETT | CGPFGNWSSP | 
    300:
    EPTCQVIQCE | PLSAPDLGIM | NCSHPLASFS | FTSACTFICS | EGTELIGKKK | 
    350:
    TICESSGIWS | NPSPICQKLD | KSFSMIKEGD | YNPLFIPVAV | MVTAFSGLAF | 
    372:
    IIWLARRLKK | GKKSKRSMND | PY
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human L-selectin
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    E0086h
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    ELISA Kit for Human L-selectin
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    E0086r
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    96T
    ELISA Kit for Human L-selectin
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    E0086b
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    ELISA Kit for Human L-selectin
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    E0086m
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    CLIA Kit for Human L-selectin
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    U0086m
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    96T
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    CLIA Kit for Human L-selectin
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    U0086b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human L-selectin
    Cat.:
    U0086h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human L-selectin
    Cat.:
    U0086r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human L-selectin
    Polyclonal Antibody for Human L-selectin
    Cat.:
    P0086Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human L-selectin
    Cat.:
    P0086Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human L-selectin
    Cat.:
    P0086Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human L-selectin
    Monoclonal Antibody for Human L-selectin
    Monoclonal Antibody for Human L-selectin
    Monoclonal Antibody for Human L-selectin
    Protein for Human L-selectin
    Protein for Human L-selectin
    Protein for Human L-selectin
    Protein for Human L-selectin

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    References
    1. 1.
      "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains."
      Siegelman M.H. , Weissman I.L.
      Proc. Natl. Acad. Sci. U.S.A.86:5562-5566(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LEU-193
      tissue: Lymphocyte.
    2. 2.
      "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins."
      Tedder T.F. , Isaacs C.M. , Ernst T.J. , Demetri G.D. , Adler D.A. , Disteche C.M.
      J. Exp. Med.170:123-133(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Tonsil.
    3. 3.
      "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor."
      Camerini D. , James S.P. , Stamenkovic I. , Seed B.
      Nature342:78-82(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-213
      tissue: Lymphocyte.
    4. 4.
      "Characterization of a human homologue of the murine peripheral lymph node homing receptor."
      Bowen B.R. , Nguyen T. , Lasky L.A.
      J. Cell Biol.109:421-427(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LEU-193
      tissue: Lymphocyte.
    5. 5.
      "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils."
      Ord D.C. , Ernst T.J. , Zhou L.J. , Rambaldi A. , Spertini O. , Griffin J. , Tedder T.F.
      J. Biol. Chem.265:7760-7767(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Hematopoietic.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      SeattleSNPs variation discovery resource
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-193; GLN-201; SER-213 AND ASP-369
    9. 9.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60
      tissue: Plasma.
    12. 12.
      "Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51."
      Bernimoulin M.P. , Zeng X.-L. , Abbal C. , Giraud S. , Martinez M. , Michielin O. , Schapira M. , Spertini O.
      J. Biol. Chem.278:37-47(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELPLG;FUNCTION
    13. 13.
      "Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin."
      Leppaenen A. , Yago T. , Otto V.I. , McEver R.P. , Cummings R.D.
      J. Biol. Chem.278:26391-26400(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELPLG
    14. 14.
      "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
      Kerr S.C. , Fieger C.B. , Snapp K.R. , Rosen S.D.
      J. Immunol.181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PODXL2
    15. 15.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60 AND ASN-104
      tissue: Leukemic T-cell.
    16. 16.
      "A template for generation and comparison of three-dimensional selectin models."
      Bajorath J. , Aruffo A.
      Biochem. Biophys. Res. Commun.216:1018-1023(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
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